Long Cui

Dec 7, 2023 | mdpi.com | Xingyu Wang |Fengkun Cui |Long Cui |Di Jiang

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Oct 17, 2023 | nature.com | Long Bai |Min Zhang |Long Cui

AbstractN6-methyladenosine (m6A) maintains maternal RNA stability in oocytes. One regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism. However, the specific role of ALKBH5 in oocyte maturation remains elusive. Here, we show that Alkbh5 depletion causes a wide range of defects in oocyte meiosis and results in female infertility. Temporal profiling of the maternal transcriptomes revealed striking RNA accumulation in Alkbh5−/− oocytes during meiotic maturation.