Lorenzo Magni

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Cryosectioning-enabled super-resolution microscopy for studying nuclear architecture at the single protein level

Feb 5, 2024 | biorxiv.org | Johannes Stein |Maria Ericsson |Michel Nofal |Lorenzo Magni

AbstractDNA-PAINT combined with total Internal Reflection Fluorescence (TIRF) microscopy enables the highest localization precisions, down to single nanometers in thin biological samples, due to TIRF's unique method for optical sectioning and attaining high contrast. However, most cellular targets elude the accessible TIRF range close to the cover glass and thus require alternative imaging conditions, affecting resolution and image quality.

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