Ltd. Shanghai

Dec 9, 2024 | onlinelibrary.wiley.com | Yong Yuan |Qi Wang |Tao Liu |Ltd. Shanghai

1 Introduction The ground penetrating shield tunnel (GPST) method, also known as ultra-rapid under pass (URUP) method, was first developed for underpass tunnel construction in densely populated areas [1]. The GPST method utilizes a tunnel boring machine (TBM) launched from the ground surface, progressively boring at larger embedment depth, coming back up to shallow embedment depth, and finally arriving at the ground level or in a shallow guide-pit.

Mar 5, 2024 | ascpt.onlinelibrary.wiley.com | Lu Liu |Kun Wang |Ltd. Shanghai |Zhongyi Sun

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Ciprofol is a highly selective GABAA receptor potentiator that is about four to five times more potent than propofol and has fewer adverse events. WHAT QUESTION DID THIS STUDY ADDRESS? What are the potential intrinsic and extrinsic covariates that can impact the pharmacokinetics (PKs) of ciprofol? Is the approved ciprofol dose regimen for mechanically ventilated patients in the intensive care unit (ICU) well-tolerated and safe?

Dec 18, 2023 | ascpt.onlinelibrary.wiley.com | Yucheng Sheng |Ltd. Shanghai |Jingru Wang |Shu-wen Teng

Overall survival is vital for approving new anticancer drugs but is often impractical for early-phase studies. The tumor growth inhibition-overall survival (TGI-OS) model could bridge the gap between early- and late-stage development. This study aimed to identify an appropriate TGI-OS model for non-small cell lung cancer (NSCLC) patients from the GEMSTONE-302 study of sugemalimab.