Lu Gan

Nov 27, 2024 | dx.doi.org | Chao Zhang |Kai Wu |Lu Gan |Xiaoyi Liu

Sep 9, 2024 | onlinelibrary.wiley.com | Xintong Li |Yuanxin Liu |Jun Gui |Lu Gan

1 Introduction Programmed death 1 (PD-1) is an inhibitory receptor (IR) that is significantly induced upon T cell activation.

Aug 4, 2024 | nature.com | Lu Gan |Wei Xie |Xiang Li |Jianping Guo

AbstractLiver fibrosis is an urgent clinical problem without effective therapies. Here we conducted a high-content screening on a natural Euphorbiaceae diterpenoid library to identify a potent anti-liver fibrosis lead, 12-deoxyphorbol 13-palmitate (DP). Leveraging a photo-affinity labeling approach, apolipoprotein L2 (APOL2), an endoplasmic reticulum (ER)-rich protein, was identified as the direct target of DP.

Mar 18, 2024 | nature.com | Yun Xia |Lu Gan

AbstractCombination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for effective combination is challenging. Here we developed a general data-driven method called CM-Drug for screening compounds that can boost ICB treatment efficacy based on core and minor gene sets identified between responsive and nonresponsive samples in ICB therapy.

Mar 11, 2024 | mdpi.com | Wei Zhang |Chen Lin |Tingting Liu |Lu Gan

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