Yun Xia

Jan 9, 2025 | insight.jci.org | JCI Insight |Bo Wang |Yun Xia |Can Zhou

AbstractCD4+ T cells contribute to antitumor immunity and are implicated in the efficacy of cancer immunotherapies. In particular, CD4+ T helper 2 (Th2) cells were recently found to block spontaneous breast carcinogenesis. However, the antitumor potential of Th2 cells in targeting established breast cancer remains uncertain.

Jun 3, 2024 | nature.com | Yun Xia |Jun Xie

AbstractThe biodegradable polymer poly-β-hydroxybutyrate (PHB) is a promising carbon source for biological mitigation of nitrogen pollution, a significant problem in aquaculture that physical and chemical methods have not provided a comprehensive solution. Here we investigated the impact of PHB on the zero-water-change largemouth bass culture by 30- and 40-day experiments.

Mar 18, 2024 | nature.com | Yun Xia |Lu Gan

AbstractCombination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for effective combination is challenging. Here we developed a general data-driven method called CM-Drug for screening compounds that can boost ICB treatment efficacy based on core and minor gene sets identified between responsive and nonresponsive samples in ICB therapy.

Feb 11, 2024 | mdpi.com | Junyi Li |Jian Yang |Yun Xia |Junyi Wang

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Oct 16, 2023 | jci.org | Mei Huang |Yun Xia |Kaiwen Li |Feng Shao

AbstractCarcinogen exposure is strongly associated with enhanced cancer immunogenicity. Increased tumor mutational burden and resulting neoantigen generation have been proposed to link carcinogen exposure and cancer immunogenicity. However, the neoantigen-independent immunological impact of carcinogen exposure on cancer is unknown.