Lu Ma

Apr 26, 2024 | mdpi.com | Haotian Liu |Lu Ma |Zhaohui Wang |Gang Qiao

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Mar 19, 2024 | nature.com | Chenguang Yang |Ming Li |Yong Huei Wang |Lu Ma

AbstractHomotypic membrane fusion of the endoplasmic reticulum (ER) is mediated by dynamin-like GTPase atlastin (ATL). This fundamental process relies on GTP-dependent domain rearrangements in the N-terminal region of ATL (ATLcyto), including the GTPase domain and three-helix bundle (3HB). However, its conformational dynamics during the GTPase cycle remain elusive. Here, we combine single-molecule FRET imaging and molecular dynamics simulations to address this conundrum.