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Jan 24, 2025 | 
nature.com | Yong Huei Wang
AbstractC–C bond cleavage and recombination provide an efficient strategy for the modification and reconstruction of molecule structures. Herein, we present a method for achieving amidation of aryl C(sp2)–H bond through the cleavage and recombination of C–C triple bond with the involvement of nitrous acid esters. This method marks the instance of precise and controlled stepwise cleavage of C–C triple bond, offering a fresh perspective for the cleavage of such bonds.
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Dec 12, 2024 | 
onlinelibrary.wiley.com | Kai Liu |Congcong Yin |Jinglin Gao |Yong Huei Wang
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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Dec 11, 2024 | 
nature.com | Haidai Hu |Philipp F. Popp |Aritz Roa-Eguiara |Nicole R. Rutbeek |Leighton J Payne |Dorentina Humolli | +8 more
AbstractZorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems1,2.
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Nov 25, 2024 | 
nature.com | Jing XUE |Yong Huei Wang
AbstractMammalian sodium-coupled high-affinity choline transporter CHT1 uptakes choline in cholinergic neurons for acetylcholine synthesis and plays a critical role in cholinergic neurotransmission. Here, we present the high-resolution cryo-EM structures of human CHT1 in apo, substrate- and ion-bound, hemicholinium-3-inhibited, and ML352-inhibited states. These structures represent three distinct conformational states, elucidating the structural basis of the CHT1-mediated choline uptake mechanism.
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Nov 24, 2024 | 
nature.com | Zhiyuan Li |Yong Huei Wang |Yilin Chen |Xi Liu |Liwei Chen |Kai Wu
AbstractNi-rich layered oxides (LiNixCoyMn1−x−yO2, x > 0.8, NCM) are technologically important cathode (i.e., positive electrode) materials for next-generation high-energy batteries. However, they face challenges in cycle stability and durability due to internal strain accumulation and particle fracture as the batteries cycle. Here we report a simple molten-salt-assisted synthesis route to introduce gradiently distributed pores into the polycrystalline NCM secondary particles.
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Nov 12, 2024 | 
mdpi.com | Tong Wu |Yong Huei Wang
1. IntroductionUntil now, many geometers have studied noncommutative residues. In [1,2], the authors found that noncommutative residues are of great importance in the study of noncommutative geometry. Wodzicki [2] first introduced the concept of the noncommutative residue in the context of higher-dimensional manifolds, namely, the noncommutative residue is a trace over the algebra of all classical pseudodifferential operators on a closed compact manifold.
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Oct 16, 2024 | 
mdpi.com | Yong Huei Wang |Dandan Li |Guirong Hou |Ziting Ma
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Aug 14, 2024 | 
mdpi.com | Li Wu |Junfeng Tian |Yanli Liu |Yong Huei Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jun 27, 2024 | 
scijournals.onlinelibrary.wiley.com | Yong Huei Wang |Huiming Zhang |Wei Fu |Juan Wang
In order to address the issues of uneven pesticide deposition and low pesticide utilization in rubber gardens caused by the traditional diffuse plant protection spraying method, this study focuses on the air-assisted powder sprayer and proposes a variable pesticide application control system. A variable pesticide application decision-making model integrating the leaf area index (LAI) was designed based on powdery mildew control standards and individual rubber tree information.
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Mar 19, 2024 | 
nature.com | Chenguang Yang |Ming Li |Yong Huei Wang |Lu Ma
AbstractHomotypic membrane fusion of the endoplasmic reticulum (ER) is mediated by dynamin-like GTPase atlastin (ATL). This fundamental process relies on GTP-dependent domain rearrangements in the N-terminal region of ATL (ATLcyto), including the GTPase domain and three-helix bundle (3HB). However, its conformational dynamics during the GTPase cycle remain elusive. Here, we combine single-molecule FRET imaging and molecular dynamics simulations to address this conundrum.
