Lucia Parolini

Jan 2, 2025 | jci.org | Garry Dolton |Hannah Thomas |Lucia Cardo |Michael Crowther |Enas M Behiry |Lucia Parolini | +8 more

AbstractThe T cell antigen presentation platform MR1 consists of 6 allomorphs in humans that differ by no more than 5 amino acids. The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant mucosal-associated invariant T (MAIT) cell subset. Recent developments suggest that the role of MR1 extends to presenting antigens from cancer cells, a function dependent on the K43 residue in the MR1 antigen binding cleft.