Michael Crowther

2 months ago | onlinelibrary.wiley.com | Joshua P. Entrop |Lasse Jakobsen |Michael Crowther |Mark Clements

1 Introduction Analyses of time-to-event data typically focus on the time until the first occurrence of an event, even when the event can occur multiple times. Including not only the first but also subsequent events, that is, performing a recurrent events analysis, might reveal more insight than the standard approach as the number of events can be useful as, for example, a marker of event intensity or severity.

Jan 2, 2025 | jci.org | Garry Dolton |Hannah Thomas |Lucia Cardo |Michael Crowther |Enas M Behiry |Lucia Parolini | +8 more

AbstractThe T cell antigen presentation platform MR1 consists of 6 allomorphs in humans that differ by no more than 5 amino acids. The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant mucosal-associated invariant T (MAIT) cell subset. Recent developments suggest that the role of MR1 extends to presenting antigens from cancer cells, a function dependent on the K43 residue in the MR1 antigen binding cleft.