Lucie Lebreuilly

2 months ago | nature.com | Lucie Lebreuilly |Samantha Samson |Anne Grießhammer |Lisa A. Maier |Thierry Naas |Didier Rognan | +2 more

AbstractThe increasing incidence of antibiotic resistance and the decline in the discovery of novel antibiotics have resulted in a global health crisis, particularly, for the treatment of infections caused by Gram-negative bacteria, for which therapeutic dead-ends are alarming. Here, we identify and characterize a molecule, NM102, that displays antimicrobial activity exclusively in the context of infection.

Jan 23, 2024 | biorxiv.org | Samantha Samson |Seav Ly Tran |Lucie Lebreuilly |Delphine Cormontagne

AbstractThe increased incidence of antibiotic resistance and declining discovery of new antibiotics have created a global health crisis, especially for the treatment of infections caused by Gram-negative bacteria. Here, we identify and characterize a molecule, NM102, that displays antimicrobial activity exclusively in the context of infection. NM102 inhibits the activity of the non-essential Mutation Frequency Decline (Mfd) protein by competing with ATP binding to its active site.