Luigino Calzetta

1 week ago | tandfonline.com | Elena Pistocchini |Mario Cazzola |Paola Rogliani |Luigino Calzetta

ABSTRACTIntroduction The journey from initial drug discovery to approval for respiratory diseases typically spans approximately 10.4 years and cost over $2.8 billion. This intricate process involves five stages: target identification, therapeutic molecule discovery, preclinical testing, clinical trials, and regulatory approval.

Nov 21, 2024 | tandfonline.com | Mario Cazzola |Luigino Calzetta |Paola Rogliani |Maria Gabriella Matera

AbstractChronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition often complicated by cardiovascular disease (CVD) due to shared inflammatory pathways. This review explores the cardiovascular impacts of emerging anti-inflammatory therapies in COPD.

Nov 20, 2024 | dovepress.com | Paola Rogliani |Luigino Calzetta

Introduction Chronic mucus hypersecretion (CMH) in chronic obstructive pulmonary disease (COPD) is associated with a decline in forced expiratory volume in the 1st second (FEV1), increased risk for pulmonary infections, elevated frequencies of exacerbations and hospitalizations, and reduced health-related quality of life (QoL).1,2 CMH is due to altered activity of goblet and submucosal gland cells as well as decreased elimination of mucus due to altered mucociliary clearance.2 Evidence from a...

Jun 11, 2024 | touchrespiratory.com | Mario Cazzola |Josuel Ora |Luigino Calzetta |Paola Rogliani

Overview Identifying patients with chronic obstructive pulmonary disease (COPD) at the earliest possible stage can achieve the best symptom control, disease progression and outcomes in COPD. However, in clinical practice, the ability to identify individuals at risk of progressing from early disease to clinically severe disease remains limited.

Nov 1, 2023 | mdpi.com | Mario Cazzola |Paola Rogliani |Josuel Ora |Luigino Calzetta

1. IntroductionThere is increasing evidence that chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) often coexist and the presence of T2DM is associated with a worse prognosis [1]. The mechanistic relationships between these two diseases are complex, multifaceted and poorly understood, but may have implications for treatment strategies. 2.