Luis Fernando Delgadillo-Silva

Jun 26, 2024 | science.org | Ellen White |Emil Gustavsson |Xinyang wang |Luis Fernando Delgadillo-Silva

AbstractCoordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement optogenetic systems to probe the role of individual β cells in the glucose response. By targeted β cell activation/inactivation in zebrafish, we reveal a hierarchy of cells, each with a different level of influence over islet-wide Ca2+ dynamics.