Lukasz Koziej

Aug 8, 2023 | nature.com | Lukasz Koziej |Igor Kaczmarczyk |Monika Gaik |Michal Rawski |Sebastian Glatt |Panagiotis Poulis

AbstractN6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding regions inhibits translation elongation. Here, we show how m6A modulates decoding in the bacterial translation system using a combination of rapid kinetics, smFRET and single-particle cryo-EM.