Luonan Chen

Nov 29, 2024 | nature.com | Luonan Chen

Dear Editor,The advancement of single-cell sequencing technology has empowered fields such as developmental biology, immunology, and oncology, underscoring its significance in revealing individual cell characteristics in health and disease. Many computational methods and workflows have been specifically designed for single-cell data analysis to accurately characterize cellular heterogeneity1.

Nov 13, 2024 | nature.com | Wangxin Guo |Lin Li |Jun Luo |Chen Hong Yu |Luonan Chen |Bin Zhou

AbstractUnipotent basal and luminal stem cells maintain prostate homeostasis, with an intermediate cell population emerging during prostate inflammation or cancer. However, the identities of basal stem cell and intermediate cell population remain unclear. Here we identified a rare intermediate cell population expressing luminal markers (termed Basal-B) with enhanced organoid formation capacity, and a larger basal population (termed Basal-A).