Lupas AN

Aug 4, 2023 | academic.oup.com | Biocomputing Group |Pier Luigi |Giovanni Madeo |Lupas AN

Coiled-coil domains (CCD) in proteins are structural motifs where α‐helices pack together in an arrangement called knobs into holes (Crick 1952, 1953a, b). Since the first crystallographic observation in the structure of influenza virus hemagglutinin (Wilson et al. 1981), CCDs have been resolved in several proteins through all the kingdoms of life (Truebestein and Leonard 2016).