M.B. El Mdawar

Jan 14, 2025 | sciencedirect.com | M.B. El Mdawar |Jessica Waibl Polania |Peter E. Fecci |Deguan Lv

Glioblastoma, the most common primary tumor of the central nervous system (CNS), remain uniformly aggressive and lethal, with a median survival of less than 2 years.1,2,3,4 Glioblastoma stem cells (GSCs) possess the fundamental stem cell properties including self-renewal, multi-potency, and tumor maintenance, and they share other characteristics with normal neural stem cells (NSCs).5,6 Although they comprise a small fraction of total tumor cells, GSCs have been demonstrated to promote tumor...

Apr 16, 2024 | sciencedirect.com | M.B. El Mdawar

Section snippetsThe structure of FcγRIIAPlatelet FcγRIIA, the Fc receptor for immunoglobulin G (IgG), was first identified as a 40,000-molecular-weight membrane protein shared by monocytes in 1985 [1]. FcγRIIA is the only Fcγ receptor expressed on human platelets, but it is not expressed on mouse platelets. The human FcγRIIA protein is encoded by the FCGR2A gene, which consists of eight exons.