M Carmen

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A genetic variant in the 3′-UTR of PIWIL4 confers risk for extreme phenotypes of male infertility by altering miR-215 and miR-136 binding affinity

2 weeks ago | academic.oup.com | Ana Isabel |M Carmen |Miguel Ángel |Maria Luisa

Infertility is currently recognized as a significant global public health concern by the World Health Organization (WHO). This condition affects ∼10–15% of couples worldwide, with male factor infertility accounting for around half of these cases (Massart et al., 2012; Tournaye et al., 2017; World Health Organization, 2017).

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