Madison Chasse

Aug 23, 2023 | biorxiv.org | Gustavo C. Cerqueira |Jaime Prout |Jessica Von Stetina |Madison Chasse

AbstractAdeno-associated viral (AAV) vectors are used to treat genetic diseases, expressing therapeutic genes from both extrachromosomal episomes and payloads that integrate into the host genome. Assays were developed to evaluate HR-mediated on-target integration and the potential occurrence of off-target integration.