Mahesh N. Sangrithi

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Single-cell RNA-seq identifies protracted mouse germline X chromosome reactivation dynamics directed by a PRC2-dependent mechanism

Jan 10, 2025 | cell.com | Yaqiong Liu |Xianzhong Lau |Prabhakaran Munusamy |Daniel Snell |Mahesh N. Sangrithi

Keywordssingle-cell RNA-seqX chromosome reactivationallele-specific expressiongerm cellsdosage compensationPRC2genome-wide reprogrammingIntroductionThe accurate transmission of genomic information over generations involves the complex regulation of chromatin in germ cells. This process, germ cell genome-wide reprogramming, initiates soon after primordial germ cell (PGC) specification very early in mammalian embryonic development.

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