Daniel Snell

Jan 10, 2025 | cell.com | Yaqiong Liu |Xianzhong Lau |Prabhakaran Munusamy |Daniel Snell |Mahesh N. Sangrithi

Keywordssingle-cell RNA-seqX chromosome reactivationallele-specific expressiongerm cellsdosage compensationPRC2genome-wide reprogrammingIntroductionThe accurate transmission of genomic information over generations involves the complex regulation of chromatin in germ cells. This process, germ cell genome-wide reprogramming, initiates soon after primordial germ cell (PGC) specification very early in mammalian embryonic development.

Nov 26, 2024 | biorxiv.org | Daniel Snell |Wazeer Varsally |Sergio Menchero |Aurélien Courtois

AbstractSex chromosomes are emerging as key regulators of adult health and disease in males (XY) and females (XX), but their impact on embryo development is poorly understood. Using single-cell RNA sequencing (scRNA-seq) on wild type and aneuploid mouse embryos, we show that sex chromosomes significantly shape the preimplantation embryo transcriptional landscape.

Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more

AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more

AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

Nov 6, 2023 | biorxiv.org | Yaqiong Liu |Xianzhong Lau |Prabhakaran Munusamy |Daniel Snell

AbstractInitiating soon after PGC specification, female germ cells undergo reactivation of the silenced X chromosome during genome wide reprogramming. However, the kinetics and dynamics of XCR in vivo have remained poorly understood. To address this here we perform a global appraisal of XCR using high-dimensional techniques.