Majd Al Suqri

May 30, 2024 | nature.com | Kathryn Weinand |Saori Sakaue |Aparna Nathan |Anna Jonsson |fan zhang |Majd Al Suqri | +5 more

AbstractSynovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of these states has yet to be defined. Here, we examine genome-wide open chromatin at single-cell resolution in 30 synovial tissue samples, including 12 samples with transcriptional data in multimodal experiments.