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Dec 30, 2024 | 
agupubs.onlinelibrary.wiley.com | John Bergkvist |Fredrik Lagergren |Rafikul Islam |David Wårlind |Paul Miller |Maj‐Lena Finnander Linderson | +2 more
1 Introduction Climate change is influencing forest ecosystems in multiple ways, causing changes in productivity, shifts in the natural distributions of species, and alterations in the frequency and intensity of climate-related disturbances (Anderegg et al., 2022; Arneth et al., 2020; Jönsson & Lagergren, 2018; Seidl et al., 2017).
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Nov 14, 2024 | 
nature.com | Ilya Korsunsky |William V Trim |Anna Jonsson |fan zhang |Kevin H-C Wei |Lydia Lynch
AbstractFibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression program in healthy synovial fibroblasts characterized by enhanced fatty acid metabolism and lipid transport.
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Nov 6, 2024 | 
avhandlingar.se | Ester Appelgren |Anna Jonsson |Marian Dörk |Patrik Åker
Nyckelord: SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; data journalism; design; data visualization; data journalism epistemology; research-through-design; boundary work; objectivity; power; autonomy; datajournalistik; design; datavisualisering; datajournalistisk epistemologi; research-through-design; gränsarbete; objektivitet; makt; autonomi; Kritisk kulturteori; Critical and Cultural Theory; Sammanfattning: This dissertation investigates the role of design in contemporary data journalism.
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Jun 11, 2024 | 
nature.com | Garrett S. Dunlap |Nida Meednu |Ruoqiao Wang |fan zhang |Anna Jonsson |Kevin H-C Wei | +11 more
AbstractRheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + T cells, including CCL5+ cells and T peripheral helper (Tph) cells, which show a prominent transcriptomic signature of recent activation and effector function.
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May 30, 2024 | 
nature.com | Kathryn Weinand |Saori Sakaue |Aparna Nathan |Anna Jonsson |fan zhang |Majd Al Suqri | +5 more
AbstractSynovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of these states has yet to be defined. Here, we examine genome-wide open chromatin at single-cell resolution in 30 synovial tissue samples, including 12 samples with transcriptional data in multimodal experiments.
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Mar 16, 2024 | 
desmog.com | Andrew Simms |Anna Jonsson |Matthew Green
Would a chicken run be sponsored by foxes, or a mouse party by cats? Not only would that be extremely provocative, it would join actors whose survival interests are in fundamental conflict. So, why is sponsorship from major climate polluters pouring into winter sports like an oil slick, just as snow sports’ very existence is threatened by global heating? It’s not a small problem, like the odd stone hidden in a snowball.
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Feb 1, 2024 | 
healio.com | Cory Perla |Shenaz Bagha |Anna Jonsson
You've successfully added Rheumatology: Rheumatoid Arthritis to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Key takeaways: Technological advances have enabled research into inflammatory subtypes. Defining inflammatory subtypes in rheumatoid arthritis may lead to tailored treatments for patients.
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Nov 29, 2023 | 
nature.com | Aparna Nathan |fan zhang |Anna Jonsson |Karthik A. Jagadeesh |Kushal Dey |Joseph Powell | +4 more
AbstractThe human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in HLA genes has been extensively documented, regulatory genetic variation modulating HLA expression levels has not been comprehensively investigated. Here we mapped expression quantitative trait loci (eQTLs) for classical HLA genes across 1,073 individuals and 1,131,414 single cells from three tissues.
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Nov 8, 2023 | 
nature.com | fan zhang |Anna Jonsson |Michelle Curtis |Maria Gutierrez-Arcelus |Javier Rangel-Moreno |Kathryne E. Marks | +18 more
AbstractRheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction1. There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined pathogenic diversity1,2. Here, to deconstruct the cell states and pathways that characterize this pathogenic heterogeneity, we profiled the full spectrum of cells in inflamed synovium from patients with rheumatoid arthritis.
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Oct 3, 2023 | 
airclim.org | Anna Jonsson
Last year hundreds of thousands of people signed up to support the idea of a ban on fossil fuel ads and sponsorships in the EU, such as the existing one on tobacco advertising. The issue is now growing – several cities, including Sydney and Stockholm, have decided to ban fossil ads and there is a good chance that it will be an issue in the election to the European Parliament 2024. The question is not if fossil fuel ads and sponsorships will be banned, it is a matter of how and when.
