Makoto Hirata

Feb 3, 2023 | nature.com | Masato Akiyama |Saori Sakaue |Kazuyoshi Ishigaki |Makoto Hirata |Koichi Matsuda |Yukihide Momozawa | +4 more

ParticipantsWe used the follow-up data of the BBJ project12. This follow-up survey from 2010 to 2014 included 141,612 participants with 32 systemic diseases at the time of participation13. We included participants genotyped by DNA genotyping array. We excluded individuals <20 years old and participants with amyotrophic lateral sclerosis. After standard quality control of genotype data (described below), we included 137,693 individuals in the analysis.