Manisha C. Yadav

Jul 19, 2024 | science.org | Ruiyi Zhang |Aashish Gupta |Min Zhu |Manisha C. Yadav

AbstractHuntingtin protein, mutated in Huntington’s disease, is implicated in nucleic acid–mediated processes, yet the evidence for direct huntingtin–nucleic acid interaction is limited. Here, we show wild-type and mutant huntingtin copurify with nucleic acids, primarily RNA, and interact directly with G-rich RNAs in in vitro assays.