Manuel Salmeron-Sanchez

Jul 10, 2024 | nature.com | Hannah Donnelly |Rio Hermantara |Karen Dunn |Jodie Hay |Helen Wheadon |Alison M. Michie | +3 more

AbstractLong-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via stem cell transplantation. The very low abundance of LT-HSCs and their rapid differentiation during in vitro culture hinders their clinical utility.

Jan 6, 2024 | biorxiv.org | Manuel Salmeron-Sanchez |Aleixandre Rodrigo-Navarro

AbstractCellular processes can be modulated by physical means, such as light, which offers advantages over chemically inducible systems with respect to spatiotemporal control. Here we introduce an optogenetic gene expression system for Lactococcus lactis that utilizes a split T7 RNA polymerase linked to two variants of the Vivid regulators.