Marc Oeller

4 weeks ago | nature.com | Florian A. Rosenberger |Sophia C. Mädler |Katrine Holtz Thorhauge |Malin Fromme |Mikhail Lebedev |Marc Oeller | +7 more

AbstractProtein misfolding diseases, including α1-antitrypsin deficiency (AATD), pose substantial health challenges, with their cellular progression still poorly understood1,2,3. We use spatial proteomics by mass spectrometry and machine learning to map AATD in human liver tissue. Combining Deep Visual Proteomics (DVP) with single-cell analysis4,5, we probe intact patient biopsies to resolve molecular events during hepatocyte stress in pseudotime across fibrosis stages.