Marck Norret

Aug 28, 2024 | pubs.rsc.org | Jessica King |Kai Chen |Cameron Evans |Marck Norret

High-Resolution Visualisation of Antisense Oligonucleotide Release from Polymers in Cells Antisense oligonucleotides (ASOs) are a well-established therapeutic modality based on RNA interference, but low cellular uptake, limited ability to direct ASO trafficking, and a range of intracellular barriers to successful activity compromise both gene silencing outcomes and clinical translations.

Aug 23, 2023 | biorxiv.org | Jessica King |Cameron Evans |Ulrich Kadolsky |Marck Norret

AbstractCancer is a heterogenous disease, with multiple cellular subpopulations present within a single tumour mass that differ genetically and morphologically, and thus respond differently to chemotherapeutics. Epithelial-to-Mesenchymal transition (EMT) has been shown to play a role in tumour heterogeneity. Single-cell sequencing is critical to identify cell-type-specific transcriptomic differences with multiplexing methods increasing experimental scope with reduced cost.

Jul 18, 2023 | cell.com | Francois Rwandamuriye |Cameron Evans |Ben Wylie |Marck Norret

Antibodies Anti-mouse CD45− BUV395 (clone 30-F11) BD Biosciences Cat: 564279; RRID: AB_2651134 Anti-mouse CD4- BUV496 (clone GK1.5) BD Biosciences Cat: 564667; RRID: AB_2722549 Anti-mouse CD3- BUV737 (clone 17A2) BD Biosciences Cat: 564380; RRID: AB_2738781 Anti-mouse Ly6C- BV421 (clone AL-21) BD Biosciences Cat: 562727; RRID: AB_2737748 Anti-mouse CD8- BV480 (clone 53-6.7) BD Biosciences Cat: 566096; RRID: AB_2739500 Anti-mouse MHCII- BV605 (clone M5/114.15.2) BD Biosciences Cat: 563413;...