Ulrich Kadolsky

Aug 23, 2023 | biorxiv.org | Jessica King |Cameron Evans |Ulrich Kadolsky |Marck Norret

AbstractCancer is a heterogenous disease, with multiple cellular subpopulations present within a single tumour mass that differ genetically and morphologically, and thus respond differently to chemotherapeutics. Epithelial-to-Mesenchymal transition (EMT) has been shown to play a role in tumour heterogeneity. Single-cell sequencing is critical to identify cell-type-specific transcriptomic differences with multiplexing methods increasing experimental scope with reduced cost.