Margaret Lowenstein

1 month ago | biorxiv.org | Margaret Lowenstein |Alejandro Ramirez |Alejandro Ramírez |Mark Field

AbstractSmall Ras-like GTPases are conserved across eukaryotes and mediate manyfunctions. Trypanosoma brucei encodes only three putative open reading framesbelonging to Ras and Rho subfamilies, all highly divergent from other taxa. Weinvestigated the most Ras-like gene product in T. brucei, TbRlp, evaluating essentiality,location and impact of blocking the GDP/GTP cycle.