Maria C. Perez-Flores

Feb 1, 2024 | eneuro.org | Jeong Han Lee |Maria C. Perez-Flores |Lauren Levine |Michael Anne Gratton

PMP22-deficient LacZ MiceAll procedures were performed under research guidelines of the Institutional Animal Care and Use Committee of the University of Nevada, Reno. Mice of either sex were studied using similar numbers. Transgenic PMP22-deficient LacZ mice were generated using the VelociGene targeting technology (Valenzuela et al., 2003), as previously reported (Amici et al., 2006).

Jan 16, 2024 | nature.com | Maria C. Perez-Flores |Seojin Park |Yingying Chen |Mincheol Kang |Phung N. Thai |Ryan Woltz | +5 more

AbstractThe inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components.