Maria C. Tanzer

Sep 17, 2024 | jci.org | Konrad Hoeft |Lars Koch |Susanne Ziegler |Ling Zhang |Maria C. Tanzer |David Schumacher | +10 more

AbstractFibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofibroblast differentiation, newly identified fibroblast populations remain ill defined, with respect to both the molecular cues driving their differentiation and their subsequent role in fibrosis.