Konrad Hoeft

Dec 4, 2024 | nature.com | Konrad Hoeft |Tore Bleckwehl |Robert Meyer |Turgay Saritas |Ingo Kurth |Sikander Hayat

AbstractSingle cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts.

Dec 4, 2024 | nature.com | Konrad Hoeft |Tore Bleckwehl |Robert Meyer |Turgay Saritas |Ingo Kurth |Sikander Hayat

AbstractSingle cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts.

Sep 17, 2024 | jci.org | Konrad Hoeft |Lars Koch |Susanne Ziegler |Ling Zhang |Maria C. Tanzer |David Schumacher | +10 more

AbstractFibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofibroblast differentiation, newly identified fibroblast populations remain ill defined, with respect to both the molecular cues driving their differentiation and their subsequent role in fibrosis.

Sep 17, 2024 | jci.org | Bernhard Dumoulin |Katalin Susztak |Konrad Hoeft |Sikander Hayat

AbstractFibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation.