Maria Elena Bottazzi

1 month ago | digitalcommons.library.tmc.edu | Richard Mahoney |Peter Hotez |Maria Elena Bottazzi

AbstractThere is broad consensus that the global response to the Covid-19 pandemic was inadequate, leading to unacceptable levels of avoidable morbidity and mortality.

Jan 9, 2025 | digitalcommons.library.tmc.edu | Sergio Castaneda |Marina Muñoz |Peter Hotez |Maria Elena Bottazzi

KeywordsMice, Animals, Disease Models, Animal, Mice, Inbred C57BL, Chagas Disease, Trypanosoma cruzi, MicrobiotaAbstractAlterations caused by Trypanosoma cruzi in the composition of gut microbiome may play a vital role in the host-parasite interactions that shapes physiology and immune responses against infection.

Apr 25, 2024 | tandfonline.com | Peter Hotez |Maria Elena Bottazzi |Cristina Poveda |Ulrich Strych

ABSTRACTIntroduction Zebrafishes represent a proven model for human diseases and systems biology, exhibiting physiological and genetic similarities and having innate and adaptive immune systems. However, they are underexplored for human vaccinology, vaccine development, and testing. Here we summarize gaps and challenges.

Oct 18, 2023 | journals.plos.org | Richard Mahoney |Peter Hotez |Maria Elena Bottazzi

Discussion The Prince Hepatitis B vaccine, the PATH/WHO Meningitis A vaccine, and the COVID vaccine technology developed at Texas Children’s CVD with LMIC manufacturers provide important lessons for the development of future vaccines including for pandemic infections that would prioritize manufacture and delivery meeting the needs of the populations in LMICs. The models lead to the identification of the following key elements: Implementation by product development partnerships led by either...

Jun 21, 2023 | ncbi.nlm.nih.gov | Peter Hotez |Maria Elena Bottazzi |David Corry

2. Immune enhancement and coronavirus vaccinesBeyond direct virus-induced pathology, immune enhancement associated with eosinophilic infiltration and immunopathology is a potential safety concern linked to first-generation vaccines to prevent severe acute respiratory syndrome (SARS) [12]. A similar phenomenon may have derailed early efforts to develop an inactivated whole virus human vaccine against respiratory syncytial virus (RSV) [13].