Mariana J. Kaplan

Jun 3, 2024 | jci.org | Mariana J. Kaplan

Autoimmune diseases (ADs) constitute about one hundred and fifty conditions that often afflict people in the prime of their life. ADs are strikingly more common in women and affect around 9% of the US population (1). Seminal work performed in the first half of the twentieth century by scientific giants such as Macfarlane, Medawar, Rose, and many others defined key concepts such as immune tolerance and immune responses to self-antigens.

Apr 12, 2024 | nature.com | Hirotsugu Oda |Kalpana Manthiram |Pallavi Pimpale Chavan |Shuichiro Nakabo |Mariël Swart |Nisa Celik | +22 more

AbstractThe linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death.

Apr 4, 2024 | acrjournals.onlinelibrary.wiley.com | Daniel Solomon |Mariana J. Kaplan |Skin Diseases |Peter A. Nigrovic

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Jan 3, 2024 | nature.com | Mariana J. Kaplan

AbstractVascular disease is a major cause of morbidity and mortality in patients with systemic autoimmune diseases, particularly systemic lupus erythematosus (SLE). Although comorbid cardiovascular risk factors are frequently present in patients with SLE, they do not explain the high burden of premature vascular disease. Profound innate and adaptive immune dysregulation seems to be the primary driver of accelerated vascular damage in SLE.