Mariano Andrés

Dec 10, 2024 | acrjournals.onlinelibrary.wiley.com | Tristan Pascart |Augustin Latourte |Sara K. Tedeschi |Mariano Andrés |Fabio Becce |Thomas Bardin | +5 more

INTRODUCTION Calcium pyrophosphate deposition (CPPD) disease occurs as a consequence of the pathological presence of calcium pyrophosphate (CPP) crystals inside joints.1-4 It is an umbrella term comprising different acute and chronic phenotypes, which often coexist.5, 6 Acute CPP crystal arthritis presents with severe joint pain and swelling, like gout flares, commonly affecting knees, wrists, and ankles and lasting for several days to weeks.7-10 These episodes can be recurrent.

Nov 5, 2024 | nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01921-5. Published online 15 October 2024. In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brackman were erroneously listed as members of the Japan Gout Genomics Consortium.

Oct 15, 2024 | nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more

AbstractGout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically independent signals (149 previously unreported loci in urate and gout).

Sep 23, 2024 | acrjournals.onlinelibrary.wiley.com | Mariano Andrés

Corresponding Author Prof. Mariano Andrés MD, PhD Senior Lecturer in Medicine (Rheumatology), Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain Consultant, Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain Researcher, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain Corresponding author: Prof.

Aug 1, 2023 | mdpi.com | Mariano Andrés

Abstract:Gout is intimately associated with cardiovascular disease—especially in cases of an atherosclerosis origin, but also with others such as heart failure, atrial fibrillation, or aortic valve stenosis. Besides the common presence of vascular comorbidities in gout sufferers, the disease is—in itself—an independent cardiovascular risk factor, with disease events and mortality attributable to having this condition.