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Jan 15, 2025 | 
opg.optica.org | Rongquan Chen |Wei Qing Wang |Ming Chen |Yuqing Song
This paper presents, to our knowledge, a novel micro-ring wavelength selective switchdevice based on a contra-directional coupler (contra-DC), whichutilizes the transparent window formed by the contra-DC to select thesingle resonant wavelength of the micro-ring resonator, avoiding thelimitation of free spectral range and realizing the function ofwavelength selection/switching.
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Nov 19, 2024 | 
nature.com | Weiqi Hong |Aqu Alu |Zimin Chen |Hongbo Hu |Haohao Dong |Jian Lei | +8 more
AbstractThe mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high safety and efficacy is paramount. In the current study, we developed a protein-based intranasal vaccine comprising the XBB.1.5 receptor binding domain (RBD)-derived trimeric recombinant protein (RBDXBB.1.5-HR) and an MF59-like oil-in-water adjuvant.
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Nov 5, 2024 | 
nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more
Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01921-5. Published online 15 October 2024. In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brackman were erroneously listed as members of the Japan Gout Genomics Consortium.
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Nov 4, 2024 | 
nature.com | Laura Spector |Wei Qing Wang |Pietro Sormanni |Monica L. Fernández-Quintero |Andrew Ward |Charlotte M. Deane | +7 more
Science is frequently subject to the Gartner hype cycle1: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology.
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Oct 23, 2024 | 
opg.optica.org | Wei Qing Wang |Ming Chen |Yuqing Song |Rongquan Chen
The current research on metasurfaces is mostly focused on its ability to manipulate electromagnetic waves in space, which requires a large number of subwavelength structures to control, thus making it difficult to avoid the problem of large device size. However, it also has great development potential in the conversion of space light to guided waves.
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Oct 15, 2024 | 
nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more
AbstractGout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically independent signals (149 previously unreported loci in urate and gout).
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Sep 18, 2024 | 
nature.com | Wei Qing Wang
AbstractKindlin-2, an adapter protein, is dysregulated in various human cancers, including triple-negative breast cancer (TNBC), where it drives tumor progression and metastasis by influencing several cancer hallmarks. One well-established role of Kindlin-2 involves the regulation of integrin signaling, achieved by directly binding to the cytoplasmic tail of the integrin β subunit.
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Aug 13, 2024 | 
mdpi.com | Rangling Li |Wei Jiang |Wei Qing Wang |Jiayu Fan
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Aug 8, 2024 | 
mdpi.com | Wenli Wang |Yanli Zhu |Wei Qing Wang |Jiamin Zhang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Aug 5, 2024 | 
nature.com | Georg Schett |Fabian Müller |Wei Qing Wang |Franco Locatelli |Carl June
AbstractChimeric antigen receptor (CAR) T cells are highly effective at targeting and eliminating cells of the B cell lineage. CAR T cell therapy has become a standard-of-care treatment for patients with relapsed or refractory B cell malignancies. In addition, the administration of genetically modified T cells with the capacity to deplete B cells and/or plasma cells has tremendous therapeutic potential in autoimmune diseases.
