
Mariette Matondo
Articles
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Dec 5, 2023 |
nature.com | Alejandro Tejada-Arranz |Thibaut Douché |Mariette Matondo |Allison Williams |Bertrand Raynal |Ben F. Luisi | +2 more
AbstractIn the gastric pathogen Helicobacter pylori, post-transcriptional regulation relies strongly on the activity of the essential ribonuclease RNase J. Here, we elucidated the crystal and cryo-EM structures of RNase J and determined that it assembles into dimers and tetramers in vitro. We found that RNase J extracted from H. pylori is acetylated on multiple lysine residues. Alanine substitution of several of these residues impacts on H. pylori morphology, and thus on RNase J function in vivo.
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