Marius Schwabenland

Nov 12, 2023 | nature.com | Julio Aguado |Atefeh Taherian Fard |Eduardo A. Albornoz |Alexander Tyshkovskiy |Marius Schwabenland |Benjamin Liang | +8 more

AbstractAging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks.