Eduardo A. Albornoz

3 weeks ago | nature.com | Rhyll E. Smythe |Eduardo A. Albornoz |Jonathan E Noonan |Trent M Woodruff |André Samson |Simone M. Schoenwaelder | +3 more

AbstractMicroangiopathy is a major complication of SARS-CoV-2 infection and contributes to the acute and chronic complications of the disease1. Endotheliopathy and dysregulated blood coagulation are prominent in COVID-19 and are considered to be major causes of microvascular obstruction1,2. Here we demonstrate extensive endothelial cell (EC) death in the microvasculature of COVID-19 organs.

Jan 15, 2025 | biorxiv.org | Ibrahim Javed |Thomas Davis |Helen Forgham |Eduardo A. Albornoz

AbstractGut bacteria have emerged as silent drivers in the pathology of Alzheimers disease (AD). They also make amyloids with structure analogue to pathological amyloids and have potential to cross-seed and propagate in a prion-like manner. AD is characterised by the accumulation of mature extracellular Amyloid-β (Aβ) plaques which are surrounded by inflammatory microglia.

Nov 12, 2023 | nature.com | Julio Aguado |Atefeh Taherian Fard |Eduardo A. Albornoz |Alexander Tyshkovskiy |Marius Schwabenland |Benjamin Liang | +8 more

AbstractAging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks.