Mark Durham

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A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain

Aug 5, 2024 | cell.com | Jessica Butts |Sih-Rong Wu |Mark Durham

Highlights•Single-cell and spatial transcriptomic atlas of the Atoh1 lineage in the hindbrain•Discovery of mature brainstem markers and caudal pons migration stream•Profiling of ATOH1 binding sites and their functional role in migration•Characterization of unipolar brush cell progenitors implicated in medulloblastomaSummaryProneural transcription factors establish molecular cascades to orchestrate neuronal diversity.

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