Sih-Rong Wu

1 month ago | cell.com | Sih-Rong Wu |Tomasz Nowakowski

Keywordsorganoidassembloidneurodevelopmentneurological disorderco-culturecell-cell interactionGet full text accessLog in, subscribe or purchase for full access. References1. Kiecker, C. ∙ Lumsden, A. The role of organizers in patterning the nervous systemAnnu. Rev. Neurosci. 2012; 35:347-3672. Lim, L. ∙ Mi, D. ∙ Llorca, A. ... Development and functional diversification of cortical interneuronsNeuron. 2018; 100:294-3133. Rakic, P. Guidance of neurons migrating to the fetal monkey neocortexBrain Res.

Aug 5, 2024 | cell.com | Jessica Butts |Sih-Rong Wu |Mark Durham

Highlights•Single-cell and spatial transcriptomic atlas of the Atoh1 lineage in the hindbrain•Discovery of mature brainstem markers and caudal pons migration stream•Profiling of ATOH1 binding sites and their functional role in migration•Characterization of unipolar brush cell progenitors implicated in medulloblastomaSummaryProneural transcription factors establish molecular cascades to orchestrate neuronal diversity.

Jan 25, 2024 | biorxiv.org | Maryam Rahimi-Balaei |Shayan Amiri |Thomas Lamonerie |Sih-Rong Wu

AbstractCerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at the early stages of cerebellar development. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip and the ventricular zone of the cerebellar primordium.

Dec 4, 2023 | biorxiv.org | Ishita Gupta |Joanna Yeung |Maryam Rahimi-Balaei |Sih-Rong Wu

AbstractIn the early cerebellar primordium, there are two progenitor zones, the ventricular zone (VZ) residing atop the IVth ventricle and the rhombic lip (RL) at the lateral edges of the developing cerebellum. These zones give rise to the several cell types that form the GABAergic and glutamatergic populations of the adult cerebellum, respectively. Recently, an understanding of the molecular compartmentation of these zones has emerged.

Jun 30, 2023 | science.org | Zhenlong Yu |Afitz Da Silva |Qing Zhang |Sih-Rong Wu

AbstractPontine nuclei (PN) neurons mediate the communication between the cerebral cortex andthe cerebellum to refine skilled motor functions. Prior studies showed that PN neurons fall into two subtypes based on their anatomic location and region-specific connectivity, but the extent of their heterogeneity and its molecular drivers remain unknown. Atoh1 encodes a transcription factor that is expressed in the PN precursors.