Markus Joppich

3 weeks ago | cell.com | Kami Pekayvaz |Badr Kilani |Markus Joppich |Luke Eivers |Sophia Brambs |Viktoria Knottenberg | +31 more

Keywords immunothrombosis thrombosis immune landscape neutrophils monocytes innate immunity single-cell multi-omics immunothrombolysis thrombus resolution immunothrombotic dysregulation thromboinflammation stroke immune-cell plasticity organ ischemia Introduction Thrombosis and thromboembolism are a major global cause of morbidity and mortality by leading to myocardial infarction, stroke, and venous thromboembolism.1,2 Simultaneously, anti-thrombotic therapies carry a relevant risk of...

Aug 29, 2024 | biorxiv.org | Markus Joppich |Rafael Kramann |Sikander Hayat |RWTH Aachen

AbstractVarious single-cell modalities covering transcriptomics, epigenetic and spatio-temporal changes in health and disease phenotypes are used in an exploratory way to understand biological systems at single-cell resolution. However, the vast amount of such single-cell data is not systematically linked to existing biomedical data. Networks have previously been used to represent harmonized biomedical data.