Sikander Hayat

Dec 4, 2024 | nature.com | Konrad Hoeft |Tore Bleckwehl |Robert Meyer |Turgay Saritas |Ingo Kurth |Sikander Hayat

AbstractSingle cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts.

Dec 4, 2024 | nature.com | Konrad Hoeft |Tore Bleckwehl |Robert Meyer |Turgay Saritas |Ingo Kurth |Sikander Hayat

AbstractSingle cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts.

Oct 23, 2024 | nature.com | Junedh Amrute |Tracy M. Yamawaki |Sikander Hayat |Andrea Bredemeyer |In-Hyuk Jung |Andrew Koenig | +9 more

AbstractInflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction1,2. However, the molecular mechanisms driving immune–fibroblast cell communication in human cardiac disease remain unexplored and there are at present no approved treatments that directly target cardiac fibrosis3,4. Here we performed multiomic single-cell gene expression, epitope mapping and chromatin accessibility profiling in 45 healthy donor, acutely infarcted and chronically failing human hearts.

Sep 18, 2024 | nature.com | Ateeq M. Khaliq |Kimia Mansouri |Asif Adil |Sikander Hayat |Mateusz Opyrchal |Meenakshi Rajamohan | +2 more

AbstractAlthough the spatial, cellular and molecular landscapes of resected pancreatic ductal adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology remain elusive. By applying spatially resolved transcriptomics to matched primary and metastatic PDAC samples, we discovered a conserved continuum of fibrotic, metabolic and immunosuppressive spatial ecotypes across anatomical regions.

Sep 17, 2024 | jci.org | Bernhard Dumoulin |Katalin Susztak |Konrad Hoeft |Sikander Hayat

AbstractFibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation.