Martin Spiess

Jul 3, 2023 | nature.com | Martin Spiess |Howard Riezman |Ludovic Enkler

AbstractLipid mobilization through fatty acid β-oxidation is a central process essential for energy production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome from where β-oxidation products enter mitochondria and fuel the tricarboxylic acid cycle. Little is known about the physical and metabolic cooperation between these organelles.

May 11, 2023 | nature.com | Samuel Itskanov |Laurie Wang |Nicolas Blanchard |Wei Shi |Martin Spiess |Rumi Sherriff | +1 more

Extended Data Fig. 1 Cryo-EM analysis of the yeast and human Sec complexes. a, A schematic of the single-particle cryo-EM analysis of the yeast Sec (ScSec) complex incubated with cotransin CP2. Note that the particles were sorted into two 3D classes, with and without Sec62, due to partial occupancy of Sec62. b, 3D reconstructions of the ScSec complex with and without ScSec62 (shown in yellow). No cotransin-like density was observed in either class.