Martin Zenke

Aug 13, 2024 | nature.com | Martin Zenke |Sikander Hayat |Turgay Saritas

AbstractEmerging evidence highlights cellular senescence’s pivotal role in chronic kidney disease (CKD). Proximal tubule epithelial cells (PTECs) and fibroblasts are major players in CKD and serve as cellular sources of senescence.

Nov 5, 2023 | nature.com | Martin Zenke |Steffen Koschmieder

Dear Editor,Myeloproliferative neoplasms (MPNs) are caused by somatic driver mutations, such as JAK2V617F, which might also affect cellular aging and senescence. Here, we analyzed the heterogeneity of aging in MPN patients and if this can be used to specifically target malignant cells. Our results indicate that cellular aging is accelerated in malignant MPN clones and this can provide a target for treatment with senolytic drugs or telomerase inhibitors.