Mary M. McDermott

Nov 4, 2024 | jamanetwork.com | Mary M. McDermott |Kristin Walter |Kirsten Bibbins-Domingo |Jennifer N. Brudno

Translational Science Reviews—A New JAMA Review Podcast (18:22) 0:00 / 0:00 Recent discoveries in basic research have major implications for improving diagnosis and treatment of human diseases.

Aug 12, 2024 | nature.com | Mary M. McDermott |Christopher Martens |Clara B Peek |Luigi Ferrucci |Philip Greenland |Charlotte A. Peterson

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-49092-5, published online 13 June 2024The abstract for this article was inadvertently truncated after the text ‘…A larger clinical trial to confirm these findings is needed.’; the following text was missing ‘Clinical Trials.gov registration: NCT03743636’. The original article has been updated.

Jun 13, 2024 | nature.com | Mary M. McDermott |Christopher Martens |Clara B Peek |Luigi Ferrucci |Philip Greenland |Charlotte A. Peterson

AbstractPeople with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respiration. Oral nicotinamide riboside (NR) increases bioavailability of NAD+ in humans.

Apr 8, 2024 | ahajournals.org | Mary M. McDermott

Lower extremity peripheral artery disease (PAD) affects between 116 and 230 million people worldwide.1 Manifestations of PAD range from asymptomatic, in which patients report no exertional leg symptoms, to chronic limb-threatening ischemia (CLTI), defined by lower-limb rest pain, gangrene, or ulceration.2 Compared with age-matched people without PAD, those with PAD have significantly higher rates of cardiovascular events and major adverse limb events (MALEs), defined as severe lower-extremity...

Feb 8, 2024 | journals.physiology.org | Ahmed Ismaeel |Mary M. McDermott |Jai Joshi |Jada C. Sturgis

Peripheral artery disease (PAD) is defined by the narrowing of the peripheral arteries to the lower extremities due to the build-up of atherosclerotic plaque (1). PAD affects over 230 million individuals globally and is a major cause of morbidity and mortality (2). PAD is also associated with exercise limitations and accelerated functional decline over time (3).