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3 weeks ago | 
nature.com | Chiara Herzog |Kejun Ying |Raghav Sehgal |Waylon J. Hastings |Alexander Tyshkovskiy |Sara Hägg | +19 more
On 1–2 November 2024, the annual Biomarkers of Aging conference welcomed academic and industry scientists, and partners from governmental and nongovernmental organizations, to Harvard Medical School in Boston, USA, to discuss new insights into measuring and monitoring human aging, with the aim of clinical translation. In this Meeting Report, we summarize the conference and offer potential future directions for the Biomarkers of Aging Consortium and the longevity science community at large.
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Jan 14, 2025 | 
medrxiv.org | Richard B Xu |Tian Qu |Megan M Marron |Luigi Ferrucci
The authors have declared no competing interest. This work was supported by the National Institute on Aging Contracts N01AG62101, N01AG62103, and N01AG62106; National Institute on Aging Grant R01AG028050; and National Institute of Nursing Research Grant R01NR012459. This work was also supported in part by the Intramural Research Program of the National Institute on Aging, Baltimore, Maryland, USA. Metabolomics in the Health ABC study were supported by National Institute on Aging Grant R01AG059729.
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Jan 12, 2025 | 
nature.com | Virginia S. Hahn |Ruin Moaddel |Joel S. Bader |Robert Gerszten |Jerome I. Rotter |Stephen S. Rich | +4 more
AbstractPeople living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure.
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Dec 5, 2024 | 
nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Oct 17, 2024 | 
nature.com | Michel Bernier |Nathan Price |Julián Candia |Yi-Han Hu |Andrew G. Deighan |Stephanie Dickinson | +6 more
AbstractBiological clocks and other molecular biomarkers of aging are difficult to implement widely in a clinical setting. In this study, we used routinely collected hematological markers to develop an aging clock to predict blood age and determine whether the difference between predicted age and chronologic age (aging gap) is associated with advanced aging in mice. Data from 2,562 mice of both sexes and three strains were drawn from two longitudinal studies of aging.
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Oct 10, 2024 | 
digitalcommons.library.tmc.edu | Vihang A. Narkar |Anurag Singh |Luigi Ferrucci |Waly Dioh
In recent years, several new classes of therapies have been investigated with their potential for restoring or improving physical functioning in older adults. These have included Mas receptor agonists, regulators of mitophagy, skeletal muscle troponin activators, anti-inflammatory compounds, and targets of orphan nuclear receptors.
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Oct 7, 2024 | 
medrxiv.org | Sarah Alexander |Danielle Hiam |Luigi Ferrucci |Annabel Critchlow
The authors have declared no competing interest. This study was funded by Australian Research Council Future Fellowship (FT210100278) and National Health and Medical Research Council (NHMRC) Australia Investigator Grant (GNT1174886). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Oct 4, 2024 | 
nature.com | Junhao Wen |Ilya M. Nasrallah |Guray Erus |Jingxuan Bao |Andrew J. Saykin |Timothy J. Hohman | +11 more
AbstractAlzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain atrophy in symptomatic mild cognitive impairment (MCI) and AD patients: the “diffuse-AD” (R1) dimension shows widespread brain atrophy, and the “MTL-AD” (R2) dimension displays focal medial temporal lobe (MTL) atrophy.
