Mary Sheehan

Jul 14, 2023 | frontiersin.org | Mary Sheehan |Carlo Biz |Daniel López-López

1. IntroductionAmputation causes disability, severely impairs human mobility and physical function, and has imposed a significant global health economic burden over the past several decades (1). The leading cause of amputation varies from region to region, peripheral vascular disease and diabetes have become the most important causes of amputation in developed countries (2, 3), which can be attributed to their escalating prevalence and the significant burden imposed on patients (4–6).