Masahide Kikkawa

May 2, 2024 | biorxiv.org | Hiroshi Yamaguchi |Masahide Kikkawa |Tomohiro Shima |Hanjin Liu

AbstractMicrotubule cytoskeletons play pivotal roles in various cellular processes, including cell division and locomotion, by dynamically changing their length and distribution in cells through tubulin polymerization/depolymerization. Recent structural studies have revealed the polymorphic lattice structure of microtubules closely correlate with the microtubule dynamics, but the studies were limited to averaged structures.

Aug 20, 2023 | febs.onlinelibrary.wiley.com | Masahide Kikkawa

Axonemal dyneins are microtubule-based motors, and they have been studied for more than 50 years since their first discovery in Tetrahymena cilia [[1, 2]]. Structural studies of axonemal dyneins have been particularly challenging due to the large size of their heavy chains (> 500 kDa). Furthermore, more than 10 isoforms of axonemal dyneins coordinately work together in the 96-nm repeating unit to generate a beating motion of micrometer-long cilia and flagella.

Apr 14, 2023 | elifesciences.org | Hiroshi Yamaguchi |Masahide Kikkawa |Katarzyna Bogucka-Janczi |Motohiro Morikawa

Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript publishedApril 14, 2023 (This version) AcceptedApril 14, 2023 ReceivedNovember 11, 2022 Share this article Cite this article Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates eLife 12:e84860.