Masaji Sakaguchi

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Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression - Nature Communications

Nov 12, 2024 | nature.com | Masaji Sakaguchi |Kimi Araki |Wei-Jun Qian |Yu-Hua Tseng |Rohit Kulkarni |C. Ronald Kahn

AbstractLipodystrophy and obesity are associated with insulin resistance and metabolic syndrome accompanied by fat tissue dysregulation. Here, we show that serine protease inhibitor A1 (SerpinA1) expression in the liver is increased during recovery from lipodystrophy caused by the adipocyte-specific loss of insulin signaling in mice.

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